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January 1, 2014International Heart JournalOpen Access

Basal Cardiomyopathy Develops in Rabbits With Ventricular Tachyarrhythmias Induced by a Single Injection of Adrenaline

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Key result

A single large-dose injection of adrenaline induced ventricular tachycardias and subsequent basal cardiomyopathy in 95.7% of rabbits, compared to 13.3% in the small-dose group.

Why the study?

Does a single injection of adrenaline induce basal cardiomyopathy in rabbits?

Population

38 fasting female rabbits weighing about 2 kg

Comparison

Intravenous infusion of a large dose of… vs Intravenous infusion of a small dose of…

Design

Preclinical

Follow-up

1 week or 3-4 weeks

Authors

TATerunao AshidaUniversity of Maryland, BaltimoreTTTetsuya TakatoThe Institute of Medical Science, Asahi Life FoundationGMGen MatsuzakiWakayama Medical University

Discussion

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Implication

No clinical implications from rabbit data; leaves open utility as model for human catecholamine cardiomyopathy.

Structured PICO

Does a single injection of adrenaline induce basal cardiomyopathy in rabbits?

P
Population
38 fasting female rabbits weighing approximately 2 kg, divided into small-dose and large-dose adrenaline groups and followed for up to 4 weeks.
I
Intervention
Intravenous infusion of a large dose of adrenaline (15-60 μg) over 10-360 seconds
C
Comparator
Intravenous infusion of a small dose of adrenaline (1-10 μg) over 10-360 seconds
O
Outcome
Development of basal cardiomyopathy assessed by pathological lesions (colloidal carbon deposits) and left ventricular basal wall movement velocity (tissue Doppler echocardiography) at 1 week or 3-4 weekssurrogate

Main Result

Absolute Event Rate: 95.7% vs 13.3%

p-value: p=<0.001

A single injection of adrenaline in rabbits induces ventricular tachyarrhythmias and subsequent reversible basal cardiomyopathy, serving as a potential model for catecholamine-induced or arrhythmogenic cardiomyopathy.

Limitations

  • Blood pressure was not measured during the study.
  • Ventriculographic demonstration of abnormal movement in the left ventricular basal segments was not carried out.
  • The origins of ventricular tachyarrhythmias were not identified.
  • Did not measure blood pressure
  • Did not carry out ventriculographic demonstration of abnormal movement
  • Origins of ventricular tachyarrhythmias were not identified

Cite This Study

Ashida et al. (2014) studied Ventricular tachyarrhythmias and basal cardiomyopathy (n=38). Adrenaline vs. 1-10 μg (small dose) was evaluated on Lesions involving all areas of the left ventricular basal portion (whole lesions) (p=<0.001). A single large-dose injection of adrenaline induced ventricular tachycardias and subsequent basal cardiomyopathy in 95.7% of rabbits, compared to 13.3% in the small-dose group.

synapsesocial.com/papers/6a830756162ea9d73e98fd63https://doi.org/10.1536/ihj.13-151

Topics

Ventricular arrhythmiasCardiomyopathyCardiac amyloidosis
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Also Consider

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