Key result
Injection of caffeine and adrenalin followed by Staphylococcus aureus in 24 rabbits resulted in gross myocardial lesions in 23 animals and myocardial abscesses in 8 animals.
Why the study?
Does a caffeine and adrenalin injection render the rabbit's heart more susceptible to abscess formation when subsequently injected with Staphylococcus aureus?
Population
24 rabbits
Design
Preclinical
Follow-up
up to three weeks
Authors
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Hypothesis-generating for synergistic myocardial injury; leaves open human translation.
Does a caffeine and adrenalin injection render the rabbit's heart more susceptible to abscess formation when subsequently injected with Staphylococcus aureus?
Preclinical evidence suggests that myocardial lesions induced by caffeine and adrenalin injections in rabbits may predispose the heart to localized abscess formation upon subsequent systemic bacterial infection.
Johnson et al. (1927) studied Myocardial lesions and abscesses (n=24). Caffeine and adrenalin followed by Staphylococcus aureus was evaluated on Gross myocardial lesion and abscess formation. Injection of caffeine and adrenalin followed by Staphylococcus aureus in 24 rabbits resulted in gross myocardial lesions in 23 animals and myocardial abscesses in 8 animals.
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