Myocardial Infarct and Arteriosclerosis Induced by Several High Molecular Substances II

The sufficient dose of several high molecular substances and a suspensoid capable of eliciting host response, i.e. bacterial polysaccharide, dextran, glycogen, and kaolin, which were shown to cause definite decrease of circulating platelets and leucocytes and to elicit adrenaline sensitizing effect, induced atheroma-like lesions of arteries, especially of coronary arteries, and grossly visible myocardial infarct and infarctlike lesions of the heart by their repetitious administration in rabbits. The diet, by which the rabbits were fed, was low in fat. The combined administration of adrenaline, (1μg per kg is sufficient dose), 30 minutes after the administration of those substances caused remarkable aggravation of the damages of the artery and of the heart, inducing sometimes giant transmural infarction with the local large coronary artery occluded. The appearance of atheroma-like lesions of the artery combined with the myocardial infarct or infarctlike lesions found in this experiment, may suggest an existence of the other avenue in the atherogenesis beside the high way of the cholesterol concept.