December 6, 2005Clinical & Experimental ImmunologyOpen Access

Phenotype of early cardiomyopathic changes induced by active immunization of rats with a synthetic peptide corresponding to the second extracellular loop of the human β1-adrenergic receptor

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Why the study?

Does immunization with beta1AR EC(II) peptide induce early stage cardiomyopathy in rats?

Population

18 Whistar Fur rats

Comparison

Immunization with a synthetic peptide… vs Vehicle injection once a month for 12 months

Design

Preclinical

Follow-up

12 months

Authors

LBLisa BuvallAstraZeneca (United Kingdom)EBEntela BollanoHeart Failure & Transplant JCJu bing ChenShanghai Jiao Tong University

Discussion

Member takes

Implication

Hypothesis-generating for beta1AR autoantibody pathogenicity in cardiomyopathy; extends preclinical models but leaves open human translation.

Structured PICO

Does immunization with beta1AR EC(II) peptide induce early stage cardiomyopathy in rats?

Population

18 Whistar Fur rats

Intervention

Immunization with a synthetic peptide corresponding to the second extracellular loop of the beta1AR (beta1AR EC(II) peptide H26R) once a month for 12 months

Comparator

Vehicle injection once a month for 12 months

Outcome

Cardiac function (fractional shortening), beta1AR autoantibodies, and beta1-adrenergic receptor kinase (GRK2) mRNA levelssurrogate

Immunization of rats with a beta1AR EC(II) peptide induces early cardiomyopathic changes, supporting the pathogenic role of beta1AR autoantibodies in dilated cardiomyopathy.

Cite This Study

Buvall et al. (2005) studied this question.

synapsesocial.com/papers/6a70e2ceb27f1581782790de https://doi.org/10.1111/j.1365-2249.2005.02986.x

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Implication

Hypothesis-generating for beta1AR autoantibody pathogenicity in cardiomyopathy; extends preclinical models but leaves open human translation.

Phenotype of early cardiomyopathic changes induced by active immunization of rats with a synthetic peptide corresponding to the second extracellular loop of the human β1-adrenergic receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Phenotype of early cardiomyopathic changes induced by active immunization of rats with a synthetic peptide corresponding to the second extracellular loop of the human β1-adrenergic receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider