Why the study?
Does combined administration of an ACE inhibitor and an angiotensin II receptor antagonist cause adverse effects in normotensive rats, and is this influenced by salt intake?
Population
Normotensive Sprague Dawley rats fed an 0.2 or 4% NaCl diet
Comparison
Combined blockade using losartan and perindopril… vs Different salt intakes (0.2% vs 4% NaCl diet)
Design
Preclinical
Follow-up
10 days
Authors
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Combined ACEI/ARB proves lethal on low-salt diets in rats; hypothesis-generating for human salt-dependent effects.
Does combined administration of an ACE inhibitor and an angiotensin II receptor antagonist cause adverse effects in normotensive rats, and is this influenced by salt intake?
Combined ACE inhibitor and ARB therapy can cause fatal adverse effects in rats on a low salt diet, which is prevented by high salt intake, likely due to angiotensinogen depletion.
Griffiths et al. (2001) studied this question.
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