Why the study?
Does the addition of eplerenone to ramipril improve renal outcomes compared to ramipril alone in a rat model of early-stage diabetic nephropathy?
Population
Wistar rats with streptozocin-induced (50 mg/kg) early-stage diabetic nephropathy
Comparison
Combination of ramipril and eplerenone for 8 weeks vs Ramipril alone for 8 weeks, as well as untreated…
Design
Preclinical
Follow-up
8 weeks
Authors
Loading...
Animal data do not support adding eplerenone to ramipril for proteinuria; leaves open its effect on hyperfiltration in human diabetic nephropathy.
Does the addition of eplerenone to ramipril improve renal outcomes compared to ramipril alone in a rat model of early-stage diabetic nephropathy?
In a rat model of early-stage diabetic nephropathy, adding eplerenone to ramipril prevents glomerular hyperfiltration but does not provide additional benefit in reducing proteinuria.
Mavrakanas et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: