Key result
In type II diabetic rats, combined treatment with eplerenone and enalapril provided the most dramatic improvements in urinary albumin excretion, GFR, and glomerulosclerosis compared to either drug alone.
Why the study?
Does eplerenone, enalapril, or their combination improve renal function in a rat model of type II diabetic nephropathy?
Population
Type II diabetic rats, normal control Long-Evans Tokushima Otsuka rats, and cultured mesangial cells
Comparison
Eplerenone, enalapril, or combination for 6 months vs Untreated OLETF rats and normal LETO rats
Design
Preclinical
Follow-up
6 months
Authors
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Hypothesis-generating for additive renoprotection with eplerenone plus enalapril; leaves open translation to human diabetic nephropathy.
Does eplerenone, enalapril, or their combination improve renal function in a rat model of type II diabetic nephropathy?
Aldosterone receptor antagonism with eplerenone provides additional benefits beyond renin-angiotensin system blockade with enalapril in a rat model of type II diabetic nephropathy.
Kang et al. (2008) studied Diabetic nephropathy in type II diabetes. Eplerenone, enalapril, and their combination vs. Normal control LETO rats and untreated OLETF rats was evaluated on Urinary albumin excretion, glomerular filtration rate, and glomerulosclerosis. In type II diabetic rats, combined treatment with eplerenone and enalapril provided the most dramatic improvements in urinary albumin excretion, GFR, and glomerulosclerosis compared to either drug alone.
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