Why the study?
Does renin-angiotensin system blockade with enalapril, losartan, or their combination reduce proteinuria, kidney hypertrophy, and plasma TGF-beta1 in streptozotocin-diabetic rats?
Population
41 male Wistar rats, including non-diabetic controls and streptozotocin (STZ 55 mg/kg)-induced diabetic rats
Comparison
Enalapril, losartan, or combination of both… vs Untreated diabetic rats and non-diabetic control…
Design
Preclinical, allocated to five groups
Follow-up
60 days
Authors
Loading...
May accelerate early antiproteinuric response with dual RAS blockade in diabetic rat models; leaves open translation to human nephropathy.
Does renin-angiotensin system blockade with enalapril, losartan, or their combination reduce proteinuria, kidney hypertrophy, and plasma TGF-beta1 in streptozotocin-diabetic rats?
In a diabetic rat model, combination therapy with an ACE inhibitor and ARB achieved an earlier antiproteinuric response than monotherapy, though long-term monotherapy was equally effective at preventing renal changes.
Erman et al. (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: