Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1999American Journal of Nephrology

Combination ACE Inhibitor and Angiotensin II Receptor Antagonist Therapy in Diabetic Nephropathy

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does the addition of losartan to ACE inhibitor therapy attenuate AngII effects (measured by plasma renin levels) in patients with diabetic nephropathy?

Population

7 inpatients with diabetic nephropathy on a usual regimen including daily oral moderate to high dose ACE…

Comparison

Oral losartan 50 mg or 100 mg daily added to… vs Usual regimen of ACE inhibitor therapy alone.

Design

Case_series

Follow-up

3 weeks

Authors

LHLee A. HebertMarquette UniversityMFMichael E. FalkenhainThe Ohio State UniversityNNN. Stanley NahmanAugusta University

Discussion

Loading...

Member takes

Implication

Should not change practice in diabetic nephropathy; leaves open whether dual blockade enhances AngII attenuation.

Structured PICO

Does the addition of losartan to ACE inhibitor therapy attenuate AngII effects (measured by plasma renin levels) in patients with diabetic nephropathy?

P
Population
7 inpatients with diabetic nephropathy on a usual regimen including daily oral moderate to high dose ACE inhibitor therapy.
I
Intervention
Oral losartan 50 mg (n=3) or 100 mg (n=4) daily added to usual ACE inhibitor therapy for 1 week.
C
Comparator
Usual regimen of ACE inhibitor therapy alone (within-subject comparison during week 1 baseline and week 3 washout).
O
Outcome
Plasma renin levelssurrogate

In a small short-term study, adding losartan to ACE inhibitor therapy in diabetic nephropathy significantly increased plasma renin levels, suggesting enhanced attenuation of AngII effects.

Limitations

  • short-term study

Cite This Study

Hebert et al. (1999) studied this question.

synapsesocial.com/papers/6a1a1cf6443d3ecd7cdf5cedhttps://doi.org/10.1159/000013417
View Full Paper
Ask AI
Bookmark
Share