April 25, 2001Clinical Science
Additive hypotensive and anti-albuminuric effects of angiotensin-converting enzyme inhibition and angiotensin receptor antagonism in diabetic spontaneously hypertensive rats
Why the study?
Does the combination of irbesartan and captopril improve blood pressure and albumin excretion in diabetic spontaneously hypertensive rats compared to monotherapy or no treatment?
Population
Diabetic spontaneously hypertensive rats
Comparison
Combination of irbesartan and captopril for 8… vs Captopril alone, irbesartan alone, and untreated…
Design
Preclinical
Follow-up
8 months
Authors
Discussion
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Implication
Additive effects in diabetic hypertensive rat model; hypothesis-generating for human trials and should not yet change practice.
Structured PICO
Does the combination of irbesartan and captopril improve blood pressure and albumin excretion in diabetic spontaneously hypertensive rats compared to monotherapy or no treatment?
P
Population
Diabetic spontaneously hypertensive rats
I
Intervention
Combination of irbesartan (15 mg/kg per day) and captopril (100 mg/kg per day) for 8 months
C
Comparator
Captopril alone (100 mg/kg per day), irbesartan alone (15 mg/kg per day), and untreated diabetic controls
O
Outcome
Blood pressure and albumin excretion ratesurrogate
Combination therapy with an ACE inhibitor and an AT1 receptor antagonist provides additive hypotensive and anti-albuminuric effects in a rat model of diabetic nephropathy.
Cite This Study
Cao et al. (2001) studied this question.