Why the study?
Does UP269-6 or captopril prevent the progression of diabetic nephropathy in uninephrectomized diabetic rats?
Population
77 uninephrectomized diabetic rats maintained with plasma glucose levels from 300 to 500 mg/dL
Comparison
UP269-6 or captopril vs Control rats receiving no additional treatment…
Design
Preclinical
Follow-up
8 months
Authors
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Both agents preserved renal histology in diabetic rats; leaves open translation to human diabetic nephropathy pending clinical trials.
Does UP269-6 or captopril prevent the progression of diabetic nephropathy in uninephrectomized diabetic rats?
Both the new ARB UP269-6 and captopril effectively reduced blood pressure and protected against renal damage in a rat model of diabetic nephropathy.
Eduardo Villa (1997) studied this question.
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