Why the study?
Clinical outcomes comparing cryoballoon ablation for pulmonary vein isolation between patients with paroxysmal AF and persistent AF had not been reported.
Does cryoballoon ablation have similar efficacy in preventing atrial tachyarrhythmia recurrences in patients with persistent atrial fibrillation compared to paroxysmal atrial fibrillation?
Does cryoballoon ablation have similar efficacy in preventing atrial tachyarrhythmia recurrences in patients with persistent atrial fibrillation compared to paroxysmal atrial fibrillation?
Cryoballoon-based pulmonary vein isolation demonstrated similar short-term efficacy for preventing atrial tachyarrhythmia recurrences in both paroxysmal and persistent atrial fibrillation, though higher antiarrhythmic drug use in the persistent group may have influenced outcomes.
CBA PVI efficacy may differ in PerAF vs PAF; leaves open need for randomized comparisons before practice change.
Background: Similar clinical outcomes have been demonstrated following pulmonary vein (PV) isolation (I) by radiofrequency catheter and cryoballoon ablation (CBA) in patients with paroxysmal atrial fibrillation (PAF). However, no comparison of the clinical outcome in patients with PAF and persistent AF (PerAF) by CBA has been reported to date. The purpose of this study was to compare the efficacy of PVI in patients with PAF and PerAF. Methods: CBA based PVI using a second-generation 28-mm balloon was performed in 58 patients with PAF and 32 with PerAF. Follow-up (FU) was based on outpatient clinic visits at 1, 3, 6, and 12 months, which included Holter electrocardiograms and ambulatory event electrocardiograms. Results: The freedom from atrial tachyarrhythmia recurrences following a single cryoballoon ablation in patients with PAF and PerAF did not differ significantly between the PAF and PerAF patients over a relatively shorter follow-up period, as estimated by the Kaplan-Meir method. Conclusion: CB-based PVI had similar efficacy for both PAF and PerAF.
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Iso et al. (2019) studied this question.
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