Phospholipase activity was first described in pancreatic juice and cobra venom at about the turn of the century. Phospholipase A2s (PLA2s)1 are those phospholipases that hydrolyze the sn-2 fatty acid acyl ester bond of phosphoglycerides to free fatty acid and lysophospholipids. PLA2s have been divided into several groups based on molecular weight, amino acid sequence and homology (e.g. position of Cys residues in the low molecular weight enzymes), calcium dependence, and cellular localization (see below).
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Jay A. Tischfield (1997) studied this question.
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