Population
Double-transgenic rats overexpressing the human renin and angiotensinogen genes, and in vitro vascular…
Comparison
Handle region decoy peptide (HRP) vs Aliskiren and vehicle
Design
Preclinical
Follow-up
7 weeks
Authors
Loading...
HRP confers no renal protection in this rat model; leaves open whether (pro)renin receptor blockade has any therapeutic role in human CKD.
The handle region decoy peptide (HRP) fails to block (pro)renin signaling or prevent renal damage in a transgenic rat model, whereas direct renin inhibition with aliskiren is protective.
Feldt et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: