A Review of the Current Status of the Chemotherapy of Tuberculosis

Article1 November 1953A REVIEW OF THE CURRENT STATUS OF THE CHEMOTHERAPY OF TUBERCULOSISWILLIAM B. TUCKER, M.D.WILLIAM B. TUCKER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-5-1045 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNo drug having been thus far found in the treatment of tuberculosis which kills all tubercle bacilli, the objectives of drug treatment in this disease still fall short of the eradication of all infecting organisms. Nevertheless, with greater understanding in recent years of the pathology of the disease, made possible largely by advances in thoracic surgery, it is now possible to state our clinical objectives more accurately.It has been found1that in pulmonary tuberculosis treated effectively with drugs for adequate periods there is little remaining reversible disease (lobular pneumonitis and tubercles without necrosis), and that the principal remaining components...Bibliography1. Medlar EM: Basic pathologic concepts, in Symposium on the treatment of pulmonary tuberculosis, Transactions of the National Tuberculosis Association, 1951, pp. 245-248. Google Scholar2. LongFerebee ERSH: A controlled investigation of streptomycin treatment in pulmonary tuberculosis, Pub. Health Rep. 65: 1419-1451 (Nov. 3) 1950. CrossrefMedlineGoogle Scholar3. Tucker WB: A controlled study of the variables in the chemotherapy of pulmonary tuberculosis, Transactions of the Twelfth Conference on the Chemotherapy of Tuberculosis, Feb. 9-12, 1953, Veterans Administration, Washington, D. C. Google Scholar4. LyghtHawkins CEJE a. : Streptomycin and dihydrostreptomycin in the treatment of tuberculosis: a comparative study, Transactions of the Twelfth Conference on the Chemotherapy of Tuberculosis. b. Cohen, S. S., Johnsen, L., Lichtenstein, M. R., and Lynch, W. J.: A comparative study of streptomycin and dihydrostreptomycin in pulmonary tuberculosis, Am. Rev. Tuberc. 68: 229-237, 1953. c. Mahady, S. C. F., Armstrong, F. L., Beck, F., Horton, R., and Lincoln, N. S.: A comparative study of streptomycin and dihydrostreptomycin in pulmonary tuberculosis, ibid. 68: 238-248, 1953. Google Scholar5. Tables on toxicity, Transactions of the Eleventh Conference on the Chemotherapy of Tuberculosis, Jan. 17-20, 1952, Veterans Administration, Washington, D. C., pp. 177-184. Google Scholar6. HeckHinshaw WHC: Clinical experience with a mixture of streptomycin and dihydrostreptomycin, Transactions of the Twelfth Conference on the Chemotherapy of Tuberculosis, Feb. 9-12, 1953, Veterans Administration, Washington, D. C. Google Scholar7. Tables on streptomycin-resistance and PAS-resistance, Transactions of the Eleventh Conference on the Chemotherapy of Tuberculosis. Google Scholar8. MitchellMeadeSteenken RSGMW: Failures of prolonged streptomycin and PAS therapy in a series of 200 consecutive cases, Transactions of the Twelfth Conference on the Chemotherapy of Tuberculosis, Feb. 9-12, 1953, Veterans Administration, Washington, D. C. Google Scholar9. HughesMardisDyeTempel FJREWECW: Combined intermittent regimens in the treatment of non-miliary pulmonary tuberculosis: a comparison of streptomycin every third day and PAS daily with streptomycin every third day and PAS every third day, Transactions of the Tenth Conference on the Chemotherapy of Tuberculosis, pp. 78-80. Google Scholar10. Tucker WB: Streptomycin therapy in the treatment of pulmonary tuberculosis: a comparison of patients treated with 0.5 gram and 1.0 gram daily for 42 days, Minutes of the Eighth Streptomycin Conference, pp. 254-274. Google Scholar11. Tables on pulmonary tuberculosis, Transactions of the Twelfth Conference on the Chemotherapy of Tuberculosis, Feb. 9-12, 1953, Veterans Administration, Washington, D. C. Google Scholar12. RobitzekSelikoff EHIJ: Hydrazine derivatives of isonicotinic acid (Rimifon, Marsilid) in the treatment of active progressive caseous pneumonic tuberculosis, Am. Rev. Tuberc. 65: 402-428, 1952. MedlineGoogle Scholar13. ElmendorfCawthonMuschenheimMcDermott DFWUCW: The absorption, distribution, excretion, and short-term toxicity of isonicotinic acid hydrazide (Nydrazid) in man, Am. Rev. Tuberc. 65: 429-442, 1952. MedlineGoogle Scholar14. ClarkElmendorfCawthonMuschenheimMcDermott CMDFWUCW: Isoniazid (isonicotinic acid hydrazide) in the treatment of miliary and meningeal tuberculosis, Am. Rev. Tuberc. 66: 391-415, 1952. MedlineGoogle Scholar15. : The treatment of pulmonary tuberculosis with isoniazid, Brit. M. J. 2: 735 (Oct. 4) 1952. CrossrefMedlineGoogle Scholar16. MountFerebee FWSH: Control study of comparative efficacy of isoniazid, streptomycin-isoniazid, and streptomycin-para-aminosalicylic acid in pulmonary tuberculosis therapy, a I. Report on twelve-week observations on 526 patients, Am. Rev. Tuberc. 66: 632-635, 1952. b. II. Report on twenty-week observations on 390 patients with streptomycin-susceptible infections, ibid. 67: 108-113, 1952. c. III. Report on 28-week observations on 649 patients with streptomycin-susceptible infections, ibid. 67: 539-543, 1953. d. The effect of streptomycin on the emergence of bacterial resistance to isoniazid, ibid. 67: 553-567, 1953. e. Transactions of Twelfth Conference on the Chemotherapy of Tuberculosis, 1953. MedlineGoogle Scholar17. HinshawD'EsopoSteenkenMuschenheimSelikoff HCNDWCIJ: Panel discussion on the correlation of the emergence of isoniazid-resistance and clinical relapse, Transactions of the Twelfth Conference on the Chemotherapy of Tuberculosis, Feb. 12, 1953, Veterans Administration, Washington, D. C. Google Scholar18. Tucker WB: Studies on the antituberculous effect of viomycin in pulmonary tuberculosis, Quarterly Progress Report, Veterans Administration Chemotherapy Committee, Washington, D. C., October, 1952; and Hobby, G.: Present status of viomycin therapy, Transactions of the Twelfth Conference on the Chemotherapy of Tuberculosis, Feb. 9-12, 1953, Veterans Administration, Washington, D. C. Google Scholar19. WarringHowlett FCKS: Allergic reactions to para-aminosalicylic acid. Report of seven cases, including one case of Löffler's syndrome, Am. Rev. Tuberc. 65: 235-249, 1952. MedlineGoogle Scholar20. MillerSandsWalkerDyeTempel FLJJRWECW: Combined daily terramycin and intermittent streptomycin in the treatment of pulmonary tuberculosis, Am. Rev. Tuberc. 66: 534-541, 1952. MedlineGoogle Scholar21. Dubos RJ: Discussion on treatment of tuberculous meningitis and survival of bacilli in tuberculous lesions, Transactions of the Eleventh Conference on the Chemotherapy of Tuberculosis, 1952; and Am. Rev. Tuberc. 65: 637-640, 1952. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *From the Symposium on Tuberculosis presented at the Thirty-Fourth Annual Session of the American College of Physicians, Atlantic City, New Jersey, April 15, 1953.From the Tuberculosis Service, Veterans Administration Hospital, and the Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcademic Medical Centers and the U.S. Department of Veterans Affairs: A 75-Year Partnership Influences Medical Education, Scientific Discovery, and Clinical CareExperimental Chemotherapy of Tuberculosis and Other Mycobacterial InfectionsTreatment of tuberculosisEmergence of Antibiotic-Resistant BacteriaMICROBIAL RESISTANCE TO ANTIBIOTICS*†MARK H. LEPPER, M.D.Present status of the chemotherapy of tuberculosisTuberculosisCurrent Concepts in the Treatment of Pulmonary TuberculosisCurrent Status of Chemotherapy of Tuberculosis 1 November 1953Volume 39, Issue 5Page: 1045-1061KeywordsClinical pathologyDrugsFallsHospital medicineInfectious diseasesNecrosisPneumonitisPulmonary diseasesThoracic surgeryTuberculosis ePublished: 1 December 2008 Issue Published: 1 November 1953 PDF downloadLoading ...