Why the study?
Does hemostatic therapy (PCC, fresh-frozen plasma, or recombinant human factor VIIa) prevent hematoma growth in a murine model of dabigatran-associated intracerebral hemorrhage?
Population
C57BL/6 mice receiving dabigatran-etexilate with induced intracerebral hemorrhage by striatal collagenase…
Comparison
Intravenous injection of prothrombin complex… vs Intravenous injection of saline
Design
Preclinical
Follow-up
24 hours
Authors
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PCC effective for dabigatran ICH in mice; hypothesis-generating for human reversal trials.
Does hemostatic therapy (PCC, fresh-frozen plasma, or recombinant human factor VIIa) prevent hematoma growth in a murine model of dabigatran-associated intracerebral hemorrhage?
In a murine model of dabigatran-associated intracerebral hemorrhage, prothrombin complex concentrate and fresh-frozen plasma effectively prevented excess hematoma expansion.
Zhou et al. (2011) studied this question.
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