Key result
Coagulation factor concentrates completely reversed dabigatran-induced prolonged bleeding time from 495±65 s to baseline levels within 5 minutes in a rat model.
Why the study?
Does the administration of coagulation factor concentrates reverse dabigatran-induced bleeding in a rat model?
Population
Rats (Hann:Wistar, 220 g BW) treated with high-dose oral dabigatran etexilate (30 mg/kg) to induce bleeding
Comparison
Intravenous administration of coagulation factor… vs Intravenous vehicle
Design
Preclinical
Follow-up
120 minutes
Authors
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May support factor concentrates for dabigatran reversal; leaves open human translation and trials.
Does the administration of coagulation factor concentrates reverse dabigatran-induced bleeding in a rat model?
Coagulation factor concentrates successfully reverse dabigatran-induced bleeding in a rat model, but standard systemic coagulation tests (aPTT, TT, ECT) fail to predict this hemostatic reversal.
Ryn et al. (2011) studied Dabigatran-induced bleeding. Coagulation factor concentrates vs. Vehicle was evaluated on Time to hemostasis (bleeding time). Coagulation factor concentrates completely reversed dabigatran-induced prolonged bleeding time from 495±65 s to baseline levels within 5 minutes in a rat model.
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