Key result
Administration of a specific antibody fragment (Fab) to rats with supratherapeutic dabigatran levels resulted in a rapid, dose-dependent reversal of blood loss.
Why the study?
Does a specific antibody fragment (Fab) against dabigatran reverse dabigatran-induced bleeding in a rat model?
Population
In vitro human plasma assays and a rat tail bleeding model
Comparison
Intravenous administration of a specific fully… vs Control (no Fab) and warfarin-treated rats
Design
Preclinical
Follow-up
6 hours
Authors
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Animal data indicate dabigatran-specific Fab potential; leaves open translation to human bleeding reversal.
Does a specific antibody fragment (Fab) against dabigatran reverse dabigatran-induced bleeding in a rat model?
A specific antibody fragment against dabigatran rapidly and safely reverses dabigatran-induced anticoagulation and bleeding in a preclinical rat model.
Ryn et al. (2012) studied Dabigatran-induced bleeding. Monoclonal antibody fragment (Fab) against dabigatran vs. Control / Warfarin was evaluated on Reversal of blood loss in rat tail bleeding model. Administration of a specific antibody fragment (Fab) to rats with supratherapeutic dabigatran levels resulted in a rapid, dose-dependent reversal of blood loss.
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