Why the study?
Adipose tissue exerts significant endocrine and metabolic effects across the body, functioning beyond simple fat storage.
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Design
Review
Adipose tissue endocrine functions may influence cardiometabolic risk; leaves open targeted interventions pending higher-level evidence.
Adipose tissue is no longer considered to be an inert tissue that stores fat.This tissue is capable of expanding to accommodate increased lipids through hypertrophy of existing adipocytes and by initiating differentiation of pre-adipocytes.Adipose tissue metabolism exerts an impact on whole-body metabolism.As an endocrine organ, adipose tissue is responsible for the synthesis and secretion of several hormones.These are active in a range of processes, such as control of nutritional intake (leptin, angiotensin), control of sensitivity to insulin and inflammatory process mediators (tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), resistin, visfatin, adiponectin, among others) and pathways (plasminogen activator inhibitor 1 (PAI-1) and acylation stimulating protein (ASP) for example).This paper reviews some of the biochemical and metabolic aspects of adipose tissue and its relationship to inflammatory disease and insulin resistance.K Ke ey y w wo or rd ds s: : adipose
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Mukherjee et al. (2023) studied this question.
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