Population
Giant cardiac membrane patches
Comparison
Extracellular sodium binding / probing at… vs Ouabain application and removal of extracellular…
Design
Preclinical
Authors
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No immediate clinical implications for ion transport therapies; leaves open whether microsecond Na,K pump kinetics translate to human cardiac models.
Fast extracellular ion binding may be the exclusive source of Na,K pump electrogenicity, demonstrating channel-like function at microsecond resolution.
Donald W. Hilgemann (1994) studied this question.
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