Acute procoagulant stress response as a dynamic measure of allostatic load in alzheimer caregivers

37 spousal Alzheimer caregivers, mean age 72 +/- 6 years

15-min speech task (acute mental stress) and assessment of negative life-events over 4 weeks

Baseline (pre-speech task)

Allostatic load (defined as the difference in procoagulability scores from baseline to speech, including plasma thrombin/antithrombin III complex, D-dimer, von Willebrand factor, tissue-type plasminogen activator, and plasminogen activator inhibitor 1 levels)surrogate