Why the study?
Does mitral valve prosthesis implantation with preservation of subvalvular apparatus improve outcomes in patients with end-stage cardiomyopathy and secondary mitral regurgitation?
Does mitral valve prosthesis implantation with preservation of subvalvular apparatus improve outcomes in patients with end-stage cardiomyopathy and secondary mitral regurgitation?
Mitral valve prosthesis implantation with subvalvular preservation and LV remodeling improves symptoms and offers 86.9% short-term survival in patients with refractory heart failure and secondary mitral regurgitation.
May improve symptoms in refractory HF with secondary MR; hypothesis-generating and requires prospective RCTs before practice change.
OBJECTIVE: To evaluate the early outcome of mitral valve prostheses implantation and left ventricular remodeling in 23 patients with end-stage cardiomyopathy and secondary mitral regurgitation (NYHA class III and IV). METHODS: Mitral valvular prosthesis implantation with preservation of papillary muscles and chordae tendinae, and plasty of anteriun cuspid for remodeling of the left ventricle. RESULTS: The surgery was performed in 23 patients, preoperative ejection fraction (echocardiography) varied from 13% to 44% (median: 30%). In 13 patients associated procedures were performed: myocardial revascularization (9), left ventricle plicature repair (3) and aortic prosthesis implantation (1). Early deaths (2) occurred on the 4th PO day (cardiogenic shock) and on the 20th PO day (upper gastrointestinal bleeding), and a late death in the second month PO (ventricular arrhythmia). Improvement occurred in NYHA class in 82. 6% of the patients (P<0.0001), with a survival rate of 86.9% (mean of 8.9 months of follow-up). CONCLUSION: This technique offers a promising therapeutic alternative for the treatment of patients in refractory heart failure with cardiomyopathy and secondary mitral regurgitation.
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Buffolo et al. (2000) studied this question.
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