Why the study?
Does statin discontinuation increase platelet activity in subjects previously treated with statins?
Population
34 subjects
Comparison
Statin discontinuation (cerivastatin) vs Continuing statin treatment (simvastatin)
Design
Cohort
Follow-up
60 days (plus 6 weeks for a subgroup)
Authors
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Statin discontinuation may heighten short-term thrombotic risk; hypothesis-generating for rebound events and needs randomized confirmation.
Does statin discontinuation increase platelet activity in subjects previously treated with statins?
Statin discontinuation leads to a transient state of platelet hyperactivation in the second week, which may contribute to the increased cardiovascular event rate observed after withdrawal.
Pasqui et al. (2003) studied this question.
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