Population
Isolated cat gastrocnemius muscle
Design
Preclinical
Authors
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Caution required for premature extrapolation in tracer studies; leaves open validation of methods for accurate volume estimation.
Monoexponential extrapolation of tracer clearance curves must be applied carefully, as premature extrapolation can lead to significant underestimation of mean transit time and volume of distribution.
Lassen et al. (1971) studied this question.
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