Why the study?
Does hypocapnia (low P(a,CO2)) predict mortality in patients with idiopathic pulmonary arterial hypertension?
Does hypocapnia (low P(a,CO2)) predict mortality in patients with idiopathic pulmonary arterial hypertension?
In patients with idiopathic pulmonary arterial hypertension, a baseline P(a,CO2) < 4.25 kPa is a strong, independent predictor of long-term mortality.
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May support risk stratification in IPAH; leaves open whether hypocapnia is causal or modifiable.
Hoeper et al. (2007) studied this question.
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