What question did this study set out to answer?

The aim is to assess if specific blood gas measurements can indicate treatment response and prognosis in patients with pulmonary arterial hypertension.

June 13, 2026European Journal of Preventive CardiologyOpen Access

Blood gas profiles reflect treatment response and prognosis in pulmonary arterial hypertension

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The aim is to assess if specific blood gas measurements can indicate treatment response and prognosis in patients with pulmonary arterial hypertension.
Analyzed arterialized capillary blood gases in 173 newly diagnosed PAH patients at baseline, and after 6 and 12 months of targeted therapy.
Calculated standardized oxygen partial pressure (pc-stdO2) using a specified formula.
Collected clinical, echocardiographic, and hemodynamic data alongside various functional and biomarker assessments.
Patients showed hypocapnia (pcCO2 = 32.5 mmHg) and moderately reduced pcO2 (67.5 mmHg) at baseline, with significantly lower pc-stdO2 (55.0 mmHg).
Under treatment, pcCO2 improved toward normocapnia, pc-stdO2 and DO2 increased significantly, while A-cDO2 decreased.
Baseline blood gas values predicted NT-proBNP levels and patient mortality (p < 0.05).

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Implication

Randomized trial evaluates blood gas measurements as indicators of treatment response in PAH, suggesting new risk stratification methods.

Cite This Study

Kramer et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf551faef96ed7f0576b2 https://doi.org/10.1093/eurjpc/zwag249.088

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Blood gas profiles reflect treatment response and prognosis in pulmonary arterial hypertension

Key Points

Discussion

Implication

Cite This Study

Blood gas profiles reflect treatment response and prognosis in pulmonary arterial hypertension

Key Points

Discussion

Implication

Cite This Study

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