February 28, 2007Acta Physiologica Hungarica

Single dose of acetylsalicylic acid in patients with Type 2 diabetes mellitus and/or chronic renal failure ameliorates anaemia by decreasing the rate of neocytolysis

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Why the study?

Does a single dose of acetylsalicylic acid improve haemopoietic status by decreasing neocytolysis in patients with Type 2 diabetes mellitus and/or chronic renal failure?

Population

55 subjects total: patients with Type 2 diabetes mellitus, patients with DM and chronic renal failure…

Comparison

Single dose of 1 gram acetylsalicylic acid (ASA) vs Non-diabetic, nonazotemic control subjects and…

Design

Cross-sectional

Authors

IWIstván WittmannUniversity of Pecs GMG MolnárUniversity of Pecs LWLászló WagnerSemmelweis University

Discussion

Member takes

Implication

May support ASA for anemia in T2DM/CRF; hypothesis-generating from Level 4 data and requires RCTs before practice change.

Structured PICO

Does a single dose of acetylsalicylic acid improve haemopoietic status by decreasing neocytolysis in patients with Type 2 diabetes mellitus and/or chronic renal failure?

Population

55 subjects total: patients with Type 2 diabetes mellitus (DM) (n=15), patients with DM and chronic renal failure (CRF) (n=15), patients with CRF without DM (n=15), and non-diabetic, nonazotemic controls (n=10).

Intervention

Single dose of 1 gram acetylsalicylic acid (ASA)

Comparator

Non-diabetic, nonazotemic control subjects and pre-treatment baseline

Outcome

Serum erythropoietin (EPO) level, reticulocyte number and rate, red blood cell count, haematocrit, haemoglobin, and serum lactate dehydrogenase activitysurrogate

A single dose of acetylsalicylic acid may ameliorate anaemia in patients with diabetes and/or chronic renal failure by increasing serum erythropoietin levels and decreasing neocytolysis.

Cite This Study

Wittmann et al. (2007) studied this question.

synapsesocial.com/papers/6a70ea81e71d69abee08ef9e https://doi.org/10.1556/aphysiol.94.2007.1-2.15

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Single dose of acetylsalicylic acid in patients with Type 2 diabetes mellitus and/or chronic renal failure ameliorates anaemia by decreasing the rate of neocytolysis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Single dose of acetylsalicylic acid in patients with Type 2 diabetes mellitus and/or chronic renal failure ameliorates anaemia by decreasing the rate of neocytolysis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider