Key result
Acetylsalicylic acid resistance prevalence did not significantly differ among patients with non-diabetic CAD (37.1%), pre-diabetes (17.6%), and type 2 diabetes (26.5%) (p=0.154).
Observational
The prevalence of acetylsalicylic acid resistance does not significantly differ between patients with T2DM, prediabetes, and non-diabetic CAD, but is independently associated with insulin use.
Aspirin resistance prevalence similar across diabetes categories in CAD; hypothesis-generating for insulin use link, prospective data needed before testing implications.
Objective: Several studies have demonstrated the beneficial role of antiplatelet therapy with acetylsalicylic acid (ASA) at atherosclerotic vascular disease. Antiaggregant effect of ASA is not uniform in all patients. Purpose of the present study is to evaluate the prevalence of ASA resistance in patients with type 2 diabetes mellitus (T2DM), pre-diabetes and non-diabetic coronary artery disease (CAD).Methods: Effect of ASA was assessed using the platelet function analyzer (PFA-100) system. Resistance to ASA was defined as a normal collagen/epinephrine induced closure time after one week of ASA therapy. Patients with non-diabetic CAD, pre-diabetes and T2DM were compared.Results: ASA resistance was found in 26 (37.1%), 6 (17.6%) and 41 (26.5%) patients in the groups, respectively (p=0.154). ASA resistance was found to be significantly higher in men, smokers and insulin users, besides this it was found to be significantly lower in beta blocker (BB) users, angiotensin converting enzyme inhibitor (ACEI) users with univariate analysis. However insulin usage was found to be the single effective parameter on ASA resistance in multivariate analysis.Conclusion: There was no difference with regard to ASA resistance between groups. While ASA resistance was higher in men, smokers and insulin users, it was lower in patients using BBs and ACEIs.doi: http://dx.doi.org/10.12669/pjms.303.4773How to cite this:Cetin M, Kiziltunc E, Cetin ZG, Cicekcioglu H, Sahin M, Isik S, et al. Acetylsalicylic acid resistance in patients with Type 2 diabetes mellitus, prediabetes & non-diabetic coronary artery disease. Pak J Med Sci 2014;30(3):539-544.
No takes yet. Share an insight, caveat, or question.
Çetın et al. (2014) conducted an observational in Type 2 diabetes mellitus, prediabetes, and non-diabetic coronary artery disease. Diabetes status (Type 2 diabetes mellitus, pre-diabetes, non-diabetic CAD) vs. Between groups was evaluated on Acetylsalicylic acid (ASA) resistance (p=0.154). Acetylsalicylic acid resistance prevalence did not significantly differ among patients with non-diabetic CAD (37.1%), pre-diabetes (17.6%), and type 2 diabetes (26.5%) (p=0.154).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: