New way to benzylic amines! Fe-catalyzed oxidative cross-coupling of electron-rich heteroarenes and methylamines is established. Under the influence of FeCl2/bipy catalyst and oxidant (pyridine N-oxide or H2O2), thiophenes, furans, indoles, and azaindoles cross-couple with methylamines to furnish the corresponding benzylic amines. An intramolecular CH/CH coupling of a thiophene is observed to afford a good ligand for the σ1 receptor protein.
No takes yet. Share an insight, caveat, or question.
Ohta et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: