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October 18, 2006Journal of Hypertension

Determinants of urinary albumin excretion reduction in essential hypertension: a long-term follow-up study

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Population

310 nondiabetic hypertensive individuals, including 252 microalbuminuric and 58 proteinuric patients

Design

Cohort

Follow-up

Mean 18 months for microalbuminuric patients; mean 25…

Authors

JPJosé M. PascualHospital Universitario de La PrincesaEREnrique RodillaUniversidad Cardenal Herrera CEUAMAmparo MirallesUniversitat de València

Discussion

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Implication

Supports UAE regression monitoring in nondiabetic hypertension with low eGFR or high DBP; leaves open causality and needs trial confirmation.

Structured PICO

P
Population
310 nondiabetic hypertensive individuals, including 252 microalbuminuric and 58 proteinuric patients
I
Intervention
Usual care including nonpharmacological treatment and/or treatment with an antihypertensive drug regime to achieve blood pressure < 135/85 mmHg
O
Outcome
Regression or significant reduction in urinary albumin excretion (defined as UAE dropping > 50% from initial values, plus reduction to < 30 mg/24 h for microalbuminuric patients and < 300 mg/24 h for proteinuric patients)surrogate

In nondiabetic hypertensive patients, the reduction of urinary albumin excretion is significantly associated with preserved baseline glomerular filtration rate and adequate blood pressure control.

Cite This Study

Pascual et al. (2006) studied this question.

synapsesocial.com/papers/6a70ecb52163a0a01bc52057https://doi.org/10.1097/01.hjh.0000249707.36393.02

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ambulatory blood pressure and microalbuminuria in essential hypertension1994 · 112 citations
  2. 2Effect of 14 years of antihypertensive treatment on renal function and urinary albumin excretion in primary hypertension1996 · 19 citations
  3. 3Left ventricular geometry and function in patients with essential hypertension and microalbuminuria1999 · 115 citations
  4. 4The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure The JNC 7 Report2003 · 25,572 citations
  5. 5Long-Term Impact of Systolic Blood Pressure and Glycemia on the Development of Microalbuminuria in Essential Hypertension2005 · 63 citations