Why the study?
Does local delivery of heparin reduce neointimal hyperplasia and percent stenosis in balloon-injured rabbit arteries?
Does local delivery of heparin reduce neointimal hyperplasia and percent stenosis in balloon-injured rabbit arteries?
Local delivery of heparin significantly inhibits neointimal hyperplasia and reduces percent stenosis after balloon arterial injury in a rabbit model without altering systemic coagulation parameters.
Hypothesis-generating for local heparin to limit restenosis; does not support clinical use without human trials.
The efficacy of local delivery of an antithrombotic drug on neointimal hyperplasia was investigated in 17 rabbits. One rabbit iliac artery was injured by a balloon catheter as a control injured artery. The other iliac artery was also injured and treated by local delivery of 25 U/kg of heparin. One hour after the balloon injury, angioscopy demonstrated an occlusive or mural thrombus in all the controls, but few in the locally-treated arteries. Four weeks after balloon injury, the percent stenosis was 34 +/- 31% in the heparin treated group (n = 7, p < 0.005) vs control side 73 +/- 17%). Accumulation of FITC-labeled heparin at the injured site was confirmed by microscopy. The activated partial thromboplastin time and fibrinogen level did not change significantly. PDGF-B chain was prominent at the neointimal layer in all the controls, whereas it was less in the locally treated arteries. Thus local delivery of heparin can inhibit neointimal hyperplasia after balloon injury by reducing thrombus-related growth stimulation.
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Tomaru et al. (1995) studied this question.
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