Key result
Cardiomyocyte-derived extracellular lncRNAs mediate cardiovascular disease progression and offer diagnostic and therapeutic targets.
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Reviews cardiomyocyte-secreted and absorbed exosomal long noncoding RNAs in cardiovascular disease, highlighting their potential as diagnostic biomarkers and therapeutic targets.
Exosomes are membrane-surrounded extracellular vesicles released by almost all cell types, which mediate intercellular communications by delivering bioactive molecules from secretory cells to recipient cells. Long noncoding RNAs (lncRNAs) are a large class of non-(protein)-coding RNAs with lengths exceeding 200 nucleotides that are very active in the development of cardiovascular diseases (CVDs). Increasing evidence suggests that exosomal lncRNAs also play important roles in the progress of CVDs. We focus on the current available studies regarding these extracellular lncRNAs secreted and absorbed by cardiomyocytes and their functional roles in CVDs, hopefully providing a basis for deeper understanding of the pathological mechanisms of CVDs and their potential for clinical diagnosis and therapy.
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Jiang et al. (2023) conducted a review in Cardiovascular diseases. Extracellular lncRNAs secreted and absorbed by cardiomyocytes was evaluated. Extracellular lncRNAs (>200 nucleotides) secreted and absorbed by cardiomyocytes play active functional roles in the progression, diagnosis, and therapy of cardiovascular diseases.
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