June 15, 2009Journal of Cardiac Surgery

Bone Marrow-Derived Stem Cells Attenuate Impaired Contractility and Enhance Capillary Density in a Rabbit Model of Doxorubicin-Induced Failing Hearts

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Why the study?

Does bone marrow-derived stem cell transplantation improve contractility and capillary density in a rabbit model of doxorubicin-induced heart failure?

Population

Rabbit model of doxorubicin-induced heart failure, n=41.

Comparison

Bone marrow-derived stem cell transplantation… vs Sham treatment or no therapy.

Design

Preclinical

Follow-up

4 weeks

Authors

JGJens GarbadeKlinikum Links der Weser SDStefan DheinElectrophysiology CLC LipinskiLeipzig Heart Institute

Discussion

Member takes

Implication

Hypothesis-generating for BMC therapy in doxorubicin cardiomyopathy; leaves open human translation pending clinical trials.

Structured PICO

Does bone marrow-derived stem cell transplantation improve contractility and capillary density in a rabbit model of doxorubicin-induced heart failure?

Population

Rabbit model of doxorubicin-induced heart failure (3 mg/kg; 6 weeks), n=41 (BMC group n=15, Medium group n=10, Dox group n=6, Healthy controls n=10).

Intervention

Bone marrow-derived stem cell (BMC) transplantation (1.5-2.0 x 10^6 cells) transplanted locally into the left ventricle.

Comparator

Sham treatment (Medium group) or no therapy (Dox group).

Outcome

Global contractility (ejection fraction and fractional shortening) and capillary density at 4 weeks post-transplantation.surrogate

In a rabbit model of doxorubicin-induced cardiomyopathy, local transplantation of autologous bone marrow-derived stem cells improved global contractility and capillary density without transdifferentiating into cardiomyocytes.

Cite This Study

Garbade et al. (2009) studied this question.

synapsesocial.com/papers/6a70ed6e2163a0a01bc520e0 https://doi.org/10.1111/j.1540-8191.2009.00844.x

Topics

Heart failure HFrEF treatment

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Bone Marrow-Derived Stem Cells Attenuate Impaired Contractility and Enhance Capillary Density in a Rabbit Model of Doxorubicin-Induced Failing Hearts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Bone Marrow-Derived Stem Cells Attenuate Impaired Contractility and Enhance Capillary Density in a Rabbit Model of Doxorubicin-Induced Failing Hearts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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