September 5, 2017Nature CommunicationsOpen Access

Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody

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Population

Coxsackievirus A6 (CVA6) particles (procapsid and A-particle)

Design

Preclinical

Authors

LXLongfa XuXiamen University QZQingbing ZhengXiamen University SLShaowei LiShandong University

Discussion

Member takes

Implication

Stable CVA6 particles may advance vaccine development; leaves open clinical immunogenicity and efficacy.

Structured PICO

Population

Coxsackievirus A6 (CVA6) particles (procapsid and A-particle)

Intervention

Cryo-EM structural analysis and complexing with a neutralizing antibody

Outcome

Atomic capsid structures and identification of an immune-dominant neutralizing epitope

The identification of the CVA6 procapsid and A-particle structures and an immune-dominant neutralizing epitope provides targets for designing anti-CVA6 vaccines.

Cite This Study

Xu et al. (2017) studied this question.

synapsesocial.com/papers/6a70edfe5d37378ac1de17e7 https://doi.org/10.1038/s41467-017-00477-9

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Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider