What is the clinical evidence from this study?

Population: Hand-foot-and-mouth disease. Intervention: X-ray crystallography. Primary outcome: Atomic structures of CVA16 particles.

August 13, 2015Journal of VirologyOpen Access

Structures of Coxsackievirus A16 Capsids with Native Antigenicity: Implications for Particle Expansion, Receptor Binding, and Immunogenicity

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Key result

High-resolution X-ray structures of mature, natural empty, and recombinant CVA16 particles revealed they are unexpanded, antigenically identical, and structurally similar to EV71.

Authors

JRJingshan RenCentre for Human Genetics XWXiangxi WangHunan University LZLing ZhuUniversity of Electronic Science and Technology of China

Discussion

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Implication

May guide CVA16 vaccine design using EV71 templates; leaves open whether structural identity confers cross-protection in humans.

PICO

Population

Hand-foot-and-mouth disease

Intervention / Comparator

X-ray crystallography

Primary Outcome

Atomic structures of CVA16 particles

Cite This Study

Ren et al. (2015) studied Hand-foot-and-mouth disease. X-ray crystallography was evaluated on Atomic structures of CVA16 particles. High-resolution X-ray structures of mature, natural empty, and recombinant CVA16 particles revealed they are unexpanded, antigenically identical, and structurally similar to EV71.

synapsesocial.com/papers/6a78a685e29fd788c9f81b4e https://doi.org/10.1128/jvi.01102-15

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Structures of Coxsackievirus A16 Capsids with Native Antigenicity: Implications for Particle Expansion, Receptor Binding, and Immunogenicity

Discussion

Member takes

Implication

PICO

Cite This Study

Structures of Coxsackievirus A16 Capsids with Native Antigenicity: Implications for Particle Expansion, Receptor Binding, and Immunogenicity

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider