Chemotherapy in drug-induced leucopenia.

flow rate without alkalinization the flow rate should be at least 12 ml./min;and (3) if the urine is weakly alkaline a flow rate of over 9 ml./min. is still required.If the case is not very severe-for example, peak plasma salicylate level not exceeding 80 mg./100 ml.-it is probably immaterial whether one adopts simple diuretic therapy, or alkalinization, or both, provided that the treatment is vigorous.However, in very severe cases it is desirable to remove salicylate from the body at the maximum possible rate, and this means com- bining very high flow rates with high urine alkalinity.Mean Salicylate Clearance* in ml. per Minute Classified According to Urine Flow Rate and Urine pH Urine Flow Rate