Population
32 Wistar rats and aortic vascular smooth muscle cells
Comparison
High-fat diet; MetS rat PVAT conditioned medium… vs Normal diet; MetS rat PVAT conditioned medium…
Design
Preclinical
Follow-up
16 weeks
Authors
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Supports leptin-p38 MAPK vascular remodeling in metabolic syndrome; hypothesis-generating, requires human validation before any clinical consideration.
In a rat model of metabolic syndrome, perivascular adipose tissue-derived leptin promotes vascular smooth muscle cell phenotypic switching via a p38 MAPK-dependent pathway, contributing to vascular remodeling.
Li et al. (2014) studied this question.
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