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May 30, 2020Journal of Clinical Laboratory AnalysisOpen Access

A four‐long noncoding RNA signature predicts survival of hepatocellular carcinoma patients

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Why the study?

Long noncoding RNAs correlate with hepatocellular carcinoma survival, but a lncRNA signature to predict patient prognostic risk needed to be identified.

Does a four-lncRNA signature predict survival in patients with hepatocellular carcinoma?

Population

180 HCC patients from Tanric and TCGA databases

Comparison

Patients stratified by a four-lncRNA prognostic signature

Design

Statistical and machine learning retrospective database analysis

Authors

HJHaitao JiangLZLianhe ZhaoYCYunjie Chen

Discussion

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Overview

LncRNA signature may refine HCC prognostication; leaves open clinical adoption pending prospective validation.

Structured PICO

Does a four-lncRNA signature predict survival in patients with hepatocellular carcinoma?

P
Population
180 patients with hepatocellular carcinoma (HCC) from public online Tanric and The Cancer Genome Atlas (TCGA) databases
I
Intervention
Four-lncRNA signature (RP11-495K9.6, RP11-96O20.2, RP11-359K18.3, and LINC00556)
O
Outcome
Survival / prognostic riskhard clinical

A four-lncRNA signature serves as an independent predictor of survival in patients with hepatocellular carcinoma.

Cite This Study

Jiang et al. (2020) studied this question.

synapsesocial.com/papers/6a70ef3bb5c1fe5ca9dfc600https://doi.org/10.1002/jcla.23377
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