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January 1, 2020BioMed Research InternationalOpen Access

Identification of Long Noncoding RNA Biomarkers for Hepatocellular Carcinoma Using Single‐Sample Networks

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Key result

A 3-lncRNA risk score independently predicts survival in patients with liver hepatocellular carcinoma.

  • n=371

Why the study?

Hepatocellular carcinoma is typically diagnosed at late stages, creating an urgent need for more effective biomarkers for early diagnosis and prognostic prediction.

Does a 3-lncRNA-based risk score model predict survival in patients with hepatocellular carcinoma?

Population

371 tumor samples of liver hepatocellular carcinoma from TCGA

Design

Bioinformatic single-sample network and prognostic modeling study

Authors

XYXiaoqing YuJZJingsong ZhangRYRui Yang

Discussion

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Member takes

Overview

Supports lncRNA-based risk scoring for HCC prognosis; leaves open clinical adoption pending prospective validation.

Study Design

Type

Observational (n=371)

Structured PICO

Does a 3-lncRNA-based risk score model predict survival in patients with hepatocellular carcinoma?

P
Population
371 tumor samples of liver hepatocellular carcinoma from The Cancer Genome Atlas used to identify and validate lncRNA biomarkers.
E
Exposure
3-lncRNA-based risk score model (RP11-150O12.3, RP11-187E13.1, and RP13-143G15.4)
O
Outcome
Survival predictionsurrogate

A novel 3-lncRNA-based risk score model was identified as an independent predictor for survival in patients with hepatocellular carcinoma.

Cite This Study

Yu et al. (2020) conducted an observational in Liver hepatocellular carcinoma (n=371). 3-lncRNA-based risk score was evaluated on Survival. A 3-lncRNA-based risk score was identified as an independent predictor for survival in patients with liver hepatocellular carcinoma.

synapsesocial.com/papers/6aa77bd8d889c65f12effd69https://doi.org/10.1155/2020/8579651
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Also Consider

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  1. 1A four‐long noncoding RNA signature predicts survival of hepatocellular carcinoma patients2020 · 6 citations
  2. 2Long non-coding RNA-based single and combination independent prognostic biomarkers for hepatocellular carcinoma2025
  3. 3The Long Noncoding RNA Expression Profile of Hepatocellular Carcinoma Identified by Microarray Analysis2014 · 59 citations
  4. 4Establishment and validation of RNA methylation-related lncRNAs signature that predicts prognosis and potential targeted therapy in hepatocellular carcinoma2026
  5. 5Investigating diagnostic potential of long non-coding RNAs in head and neck squamous cell carcinoma using TCGA database and clinical specimens2024 · 10 citations