Key result
Microarray analysis identified 214 lncRNAs and 338 mRNAs abnormally expressed in hepatocellular carcinoma tissues compared to adjacent non-tumor tissues (Fold Change ≥2.0, P<0.05).
Why the study?
What is the long noncoding RNA expression profile in hepatocellular carcinoma compared to adjacent non-tumor tissue?
Population
22 pairs of human hepatocellular carcinoma and adjacent non-tumor tissues
Comparison
lncRNA and mRNA expression profiling via… vs Adjacent non-tumor (NT) tissues
Design
Preclinical
Authors
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May nominate lncRNA candidates for HCC biomarker research; leaves open validation and mechanistic roles in prospective studies.
Observational (n=19)
No
What is the long noncoding RNA expression profile in hepatocellular carcinoma compared to adjacent non-tumor tissue?
Effect estimate: Fold Change ≥2.0
p-value: p=<0.05
The study identifies a specific lncRNA expression profile associated with hepatocellular carcinoma, providing potential new biomarkers or therapeutic targets for HCC pathogenesis.
Zhu et al. (2014) conducted an observational in Hepatocellular Carcinoma (n=19). Hepatocellular carcinoma (tumor tissue) vs. Adjacent non-tumor tissue was evaluated on Differentially expressed lncRNAs and mRNAs (Fold Change ≥2.0, p=<0.05). Microarray analysis identified 214 lncRNAs and 338 mRNAs abnormally expressed in hepatocellular carcinoma tissues compared to adjacent non-tumor tissues (Fold Change ≥2.0, P<0.05).
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