What question did this study set out to answer?

To evaluate the procedural success, clinical outcomes, and complication rates of catheter ablation for atrial fibrillation in patients over 75 years of age.

March 21, 2008Journal of Cardiovascular Electrophysiology

Efficacy, Safety, and Outcome of Atrial Fibrillation Ablation in Septuagenarians

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Why the study?

Does catheter ablation for atrial fibrillation maintain sinus rhythm and have an acceptable safety profile in patients over 75 years of age?

Population

174 consecutive patients over 75 years of age with atrial fibrillation

Design

Cohort

Follow-up

mean 20 +/- 14 months

Authors

ACAndrea CorradoAdvanced Composite Products (United States)DPDimpi PatelNational Jewish Health LRLucie RiedlbauchováCharles University

Discussion

Member takes

Implication

AF ablation may maintain sinus rhythm with low complications in selected patients >75; hypothesis-generating and should not yet change practice.

Key Points

To evaluate the procedural success, clinical outcomes, and complication rates of catheter ablation for atrial fibrillation in patients over 75 years of age.
Analyzed 174 consecutive patients aged >75 years (55% paroxysmal AF, 65% with CHADS score ≥2) who underwent AF ablation between 2001 and 2006.
Assessed maintenance of sinus rhythm, redo procedure efficacy, and complication rates over a mean follow-up of 20 ± 14 months.
Sinus rhythm was maintained in 73% of patients (127/174) after a single ablation, and 80% (16/20) of those undergoing a second procedure achieved success.
Major acute procedural complications occurred in 1.0% of cases (2/194: one cerebrovascular accident and one hemothorax), with three additional strokes occurring within 6 weeks post-ablation.
Warfarin was successfully discontinued in 96% of patients (138/143) who maintained sinus rhythm without antiarrhythmic medications, with zero embolic events over 16 ± 12 months.

Structured PICO

Does catheter ablation for atrial fibrillation maintain sinus rhythm and have an acceptable safety profile in patients over 75 years of age?

Population

174 consecutive patients over 75 years of age with atrial fibrillation (55% paroxysmal, 65% with CHADS score ≥2)

Intervention

Catheter ablation for atrial fibrillation

Outcome

Success rate (maintenance of sinus rhythm), outcome, and complication rate

Catheter ablation for atrial fibrillation in septuagenarians is effective for maintaining sinus rhythm and has an acceptable safety profile, allowing for warfarin discontinuation in the majority of successful cases.

Cite This Study

Corrado et al. (2008) studied this question.

synapsesocial.com/papers/6a70efe3fe4101aa97e0609e https://doi.org/10.1111/j.1540-8167.2008.01124.x

Topics

Atrial fibrillation Persistent AF management AF ablation outcomes Anticoagulation in AF

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Implication

AF ablation may maintain sinus rhythm with low complications in selected patients >75; hypothesis-generating and should not yet change practice.

Efficacy, Safety, and Outcome of Atrial Fibrillation Ablation in Septuagenarians

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Efficacy, Safety, and Outcome of Atrial Fibrillation Ablation in Septuagenarians

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider