Why the study?
Does antecedent nocturnal hypoglycemia alter cognitive dysfunction during subsequent hypoglycemia in patients with type 1 diabetes?
Population
15 patients with type 1 diabetes mellitus (T1DM) and 12 nondiabetic control subjects
Comparison
Nocturnal hypoglycemia prior to morning… vs Nocturnal euglycemia prior to morning…
Design
RCT, in random sequence
Authors
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Nocturnal hypoglycemia may blunt cognitive effects of later episodes in T1DM; extends RCT evidence for adaptive glycemic threshold shifts.
Does antecedent nocturnal hypoglycemia alter cognitive dysfunction during subsequent hypoglycemia in patients with type 1 diabetes?
Antecedent nocturnal hypoglycemia shifts the glycemic thresholds for hypoglycemic cognitive dysfunction to lower plasma glucose concentrations in patients with T1DM.
Fanelli et al. (1998) studied this question.
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