Key result
Recent antecedent hypoglycemia fails to lower glycemic thresholds for cognitive dysfunction in healthy nondiabetics.
Why the study?
It was uncertain whether glycemic thresholds for hypoglycemic cognitive dysfunction shift to lower plasma glucose concentrations after recent antecedent hypoglycemia in nondiabetic humans.
Does recent antecedent hypoglycemia reduce hypoglycemic cognitive dysfunction during subsequent hypoglycemia in healthy young adults?
Population
16 healthy young adult subjects (7 women and 9 men)
Comparison
Hyperinsulinemic hypoglycemia vs hyperinsulinemic euglycemia between 1430 and 1630
Design
Randomized controlled trial with random sequence
Follow-up
The following morning
Authors
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Antecedent hypoglycemia may shift cognitive thresholds lower in healthy adults; leaves open relevance to unawareness in diabetes.
RCT (n=16)
Random sequence
Does recent antecedent hypoglycemia reduce hypoglycemic cognitive dysfunction during subsequent hypoglycemia in healthy young adults?
Unlike neuroendocrine and symptomatic responses, glycemic thresholds for cognitive dysfunction do not shift to lower glucose concentrations after recent antecedent hypoglycemia in nondiabetic humans.
Hvidberg et al. (1996) conducted an RCT in Healthy nondiabetic humans (n=16). Hyperinsulinemic hypoglycemia vs. Hyperinsulinemic euglycemia (4.8 +/- 0.1 mmol/l) was evaluated on Hypoglycemic cognitive dysfunction during stepped hypoglycemic clamps. Recent antecedent hypoglycemia did not significantly shift glycemic thresholds for hypoglycemic cognitive dysfunction to lower plasma glucose concentrations in healthy nondiabetic humans.
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