Key result
Antecedent hypoglycemia of 3.9 mmol/l and 3.3 mmol/l produced a hierarchy of significantly blunted counterregulatory responses to subsequent hypoglycemia in healthy men (P<0.01).
Why the study?
Do differing levels of antecedent hypoglycemia blunt subsequent counterregulatory responses to hypoglycemia in healthy men?
Population
8 healthy, overnight-fasted male subjects
Comparison
Antecedent hypoglycemia induced by insulin… vs Clamped euglycemia on day 1
Design
RCT, four separate randomized occasions
Follow-up
2-day protocols
Authors
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Mild antecedent hypoglycemia impairs subsequent counterregulation in healthy men; confirms dose-dependent blunting and supports minimizing episodes to preserve defenses.
RCT (n=8)
Crossover
Do differing levels of antecedent hypoglycemia blunt subsequent counterregulatory responses to hypoglycemia in healthy men?
p-value: p=<0.01
In healthy men, the depth of antecedent hypoglycemia determines a hierarchy of blunted counterregulatory responses to subsequent hypoglycemia.
Davis et al. (1997) conducted an RCT in Healthy volunteers (n=8). Antecedent hypoglycemia vs. Antecedent euglycemia (plasma glucose 5.2 mmol/l) was evaluated on Autonomic, neuroendocrine, and metabolic counterregulatory responses to subsequent hypoglycemia (p=<0.01). Antecedent hypoglycemia of 3.9 mmol/l and 3.3 mmol/l produced a hierarchy of significantly blunted counterregulatory responses to subsequent hypoglycemia in healthy men (P<0.01).
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