Why the study?
Does the duration of antecedent hypoglycemia affect the magnitude of subsequent counterregulatory failure in healthy humans?
Population
31 lean healthy overnight-fasted individuals (16 men/15 women)
Comparison
Antecedent hypoglycemia of differing durations… vs Antecedent euglycemia on day 1
Design
RCT, randomized experiments
Follow-up
2 days
Authors
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Even brief antecedent hypoglycemia blunts counterregulatory responses; confirms duration does not modulate subsequent failure in healthy humans.
Does the duration of antecedent hypoglycemia affect the magnitude of subsequent counterregulatory failure in healthy humans?
Even short-duration prior hypoglycemia can significantly blunt key neuroendocrine and metabolic counterregulatory responses to subsequent hypoglycemia in healthy humans.
Davis et al. (2000) studied this question.
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