Why the study?
Does antecedent physiologic increase of plasma cortisol blunt counterregulatory responses to subsequent hypoglycemia in healthy men?
Population
16 lean, healthy, overnight fasted male subjects
Comparison
Antecedent physiologic increases of plasma… vs Antecedent euglycemia without cortisol infusion
Design
RCT, randomized experiments
Follow-up
2 days
Authors
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May heighten hypoglycemia-associated autonomic failure risk after stress; confirms cortisol mediation via RCT in healthy men.
Does antecedent physiologic increase of plasma cortisol blunt counterregulatory responses to subsequent hypoglycemia in healthy men?
Antecedent physiologic increases in plasma cortisol blunt counterregulatory responses to subsequent hypoglycemia, suggesting cortisol mediates hypoglycemia-associated autonomic failure.
Davis et al. (1996) studied this question.
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