Key result
Mild hypoglycemia impaired performance on the trail making test (-19.3 vs 1.2 targets/min, P<0.05) and digit-symbol substitution test (18 vs 29 symbols/min, P<0.03) compared to euglycemia.
Why the study?
Does mild hypoglycemia impair psychomotor performance and counterregulatory responses in healthy volunteers?
Population
12 healthy volunteers
Comparison
Mild hypoglycemia via modified hyperinsulinemic… vs Euglycemia via modified hyperinsulinemic glucose…
Design
Other
Follow-up
95 minutes per clamp session
Authors
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Mild hypoglycemia may impair cognition; hypothesis-generating for real-world function and glycemic targets in diabetes.
Does mild hypoglycemia impair psychomotor performance and counterregulatory responses in healthy volunteers?
Absolute Event Rate: 18% vs 29%
p-value: p=<.03
Mild hypoglycemia selectively impairs psychomotor performance in healthy volunteers, but this impairment occurs after the onset of glucose counterregulation and warning symptoms.
Stevens et al. (1989) studied Healthy volunteers (n=12). Mild hypoglycemia vs. Euglycemia (4.9 mM) was evaluated on Digit-symbol substitution (DSS) test performance (symbols/min) (p=<.03). Mild hypoglycemia impaired performance on the trail making test (-19.3 vs 1.2 targets/min, P<0.05) and digit-symbol substitution test (18 vs 29 symbols/min, P<0.03) compared to euglycemia.
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