December 1, 1990Diabetes
Mild Hypoglycemia and Impairment of Brain Stem and Cortical Evoked Potentials in Healthy Subjects
Key result
Mild hypoglycemia alters brain stem and cortical auditory responses in ~88% of subjects versus euglycemia.
- n=16
Why the study?
The impact of mild hypoglycemia on central nervous system function in healthy adults was not well characterized.
Does mild hypoglycemia impair brain stem and cortical evoked potentials in healthy adults?
Comparison
Hypoglycemic insulin clamp vs euglycemic insulin clamp
Design
Physiological clamp study measuring brain stem and cortical evoked potentials
Authors
Discussion
Loading...
Member takes
Implication
Mild hypoglycemia may impair auditory evoked potentials in healthy adults; hypothesis-generating and leaves open clinical relevance or practice implications.
Structured PICO
Does mild hypoglycemia impair brain stem and cortical evoked potentials in healthy adults?
P
Population
16 healthy adults undergoing hypoglycemic or euglycemic insulin clamps to evaluate the impact of mild hypoglycemia on CNS function.
I
Intervention
Hypoglycemic insulin clamp (80 mU.m-2.min-1) with plasma glucose reduced from 4.6 to 3 mM in hourly approximately 0.5-mM steps
C
Comparator
Euglycemic insulin clamp (80 mU.m-2.min-1) with plasma glucose maintained at baseline levels
O
Outcome
Brain stem auditory evoked potentials and P300 potentialssurrogate
Main Result
Absolute Event Rate: 87.5% vs 0%
Mild hypoglycemia (3 mM) in healthy adults causes reversible impairments in both brain stem and cortical neural function that coincide with symptom onset.
Cite This Study
Jones et al. (1990) studied Healthy adults (n=16). Hypoglycemic insulin clamp vs. Euglycemic insulin clamp was evaluated on Alteration in wave V component of the brain stem potential. Mild hypoglycemia (to 3 mM) produced marked alterations in brain stem and cortical responses to auditory stimuli, altering the wave V component in 87.5% of subjects.