Why the study?
To identify and compare the prevalence of drug-drug interactions in the cardiac intensive care units of two tertiary care hospitals and analyze their association with various predictors.
There is an extremely high prevalence of potential drug-drug interactions in cardiac intensive care units, strongly associated with polypharmacy, highlighting the need for better monitoring.
High DDI prevalence in CCUs signals need for screening; leaves open whether interventions improve outcomes.
OBJECTIVES: To identify and compare the prevalence of drug-drug interactions (DDIs) in the intensive cardiac care units (CCUs) of 2 tertiary care hospitals and analyze their association with various predictors. Methods: This one-year prospective cross-sectional study was conducted in 2 tertiary care hospitals of Peshawar, Khyber Teaching Hospital (KTH) and Hayatabad Medical Complex (HMC), Peshawar, Pakistan, between January 2014 to Janury 2015. The patient medication profiles from the respective CCUs were evaluated for potential DDIs (PDDIs) using Micromedex DrugReax and Drug interaction facts. Results: The prevalence of PDDIs was 96.5% and 95.7% in the 2 hospitals, with over 1200 PDDIs in total. A significant association was found between the number of prescribed drugs and PDDIs in both hospitals. Conclusion: The knowledge of PDDIs is either lacking among the clinicians or is not taken into consideration. Monitoring PDDIs and timely interventions are required to minimize the adverse outcomes.
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Shakeel et al. (2018) studied this question.
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