Why the study?
Does ramipril modulate ACE2 expression and activity in the retina of diabetic rats?
Does ramipril modulate ACE2 expression and activity in the retina of diabetic rats?
ACE2 is present and catalytically active in the rodent retina, with its activity increasing in diabetes and remaining unaffected by ACE inhibition with ramipril.
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Retinal ACE2 upregulation persists despite ramipril in diabetic models; hypothesis-generating for RAS-targeted retinopathy therapies pending human data.
Tikellis et al. (2004) studied this question.
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